Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems
نویسندگان
چکیده
منابع مشابه
Autoantibodies in autoimmune polyglandular syndrome type I patients react with major brain neurotransmitter systems.
Patients with autoimmune polyglandular syndrome type I (APS1) often display high titers of autoantibodies (autoAbs) directed against aromatic L-amino acid decarboxylase (AADC), tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH), and glutamic acid decarboxylase (GAD). Neurological symptoms, including stiff-man syndrome and cerebellar ataxia, can occur in subjects with high levels of GAD aut...
متن کاملPolyglandular autoimmune syndrome-type I.
Polyglandular autoimmune syndrome type I is a rare disorder characterized by mucocutaneous candidiasis (MC), hypoparathyroidism (HP) and adrenal insufficiency , requiring regular follow up as the components of the syndrome appear at different age groups. We report a six and half year boy having this syndrome and presenting with MC, HP and ectodermal dystrophy.
متن کاملErythema annulare centrifugum: association with autoimmune polyglandular syndrome type 1
Autoimmune polyendocrine syndromes are a heterogeneousgroup of rare diseases characterized by autoimmune activityagainst more than one endocrine organ, although non-endocrineorgans can also be affected. We report the association of APS Iwith erythema annulare centrifugum in an 18-years-old male whopresented with multiple figurate erythema spreading on his trunkand extremities along with a histo...
متن کاملPolyglandular autoimmune syndrome type II.
The polyglandular autoimmune syndromes (PAS) comprise a wide spectrum of autoimmune disorders. There exist a juvenile (PAS I) and an adult type (PAS II). The nature of PAS has been based on the presence of lymphocyte infiltration in the affected gland, organ-specific antibodies in the serum, cellular immune defects and an association with the human leucocyte antigen (HLA) DR/DQ genes or immune ...
متن کاملAutoimmune polyglandular syndrome, type II.
The combination of autoimmune adrenal insufficiency with autoimmune thyroid disease and/or type 1 autoimmune diabetes mellitus defines autoimmune polyglandular syndrome, type II. The conditions may occur in any order, and diagnosis is confounded by the nonspecific nature of the symptoms of adrenal insufficiency and hypothyroidism. The disorder is not common, but consequences can be life threate...
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ژورنال
عنوان ژورنال: The Journal of Comparative Neurology
سال: 2009
ISSN: 0021-9967,1096-9861
DOI: 10.1002/cne.21962